Anti-high mobility group box 1 monoclonal antibody ameliorates experimental autoimmune encephalomyelitis
نویسندگان
چکیده
منابع مشابه
Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats.
The high mobility group box-1 (HMGB1), originally identified as an architectural nuclear protein, exhibits an inflammatory cytokine-like activity in the extracellular space. Here we show that treatment with neutralizing anti-HMGB1 monoclonal antibody (mAb; 200 microg, twice) remarkably ameliorated brain infarction induced by 2-h occlusion of the middle cerebral artery in rats, even when the mAb...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2013
ISSN: 0009-9104
DOI: 10.1111/cei.12036